Sarcina si bolile autoimune (3)
Raspunsuri - Pagina 14
bobocut spune:
La Multi Ani si 2010 sa va aduca implinirea visului vostru cel mai drag!
Mie mi-au venit rezultatele de la analizele imunologice facute la Babes. Mi-a iesit Factorul Anti-Nuclear (ANA) pozitiv (valorile pozitive sunt de la "+" la "+++" si eu am un "+"). La Observatii scrie: "Prezenta de autoanticorpi anti-nucleari in titru mic (<1/80)". La concluzii scrie: "Posibil proces cu componenta autoimuna minima". Mai are cineva un asemenea rezultat?
Va pup
bobocut
mihaele spune:
La multi ani fetelor anul 2010 sa va aduca bebei mult doriti.
bobocut da eu am acelasi rezultat ca al tau identic. Si nu a stiut nimeni sa-mi spuna ce este de facut. Tie tia spus cineva ceva te-a lamurit cineva?
Puisori dragalasi
ANITA75 spune:
buna fetelor!
am fost la un control la dr. Bajenaru acum vreun an jumate m-a pus sa-mi fac analize si mi-a iesit asa
TPO-683.99
FREE T4-1.20
TSH-2.09
A zis ca-i mare TPO dar nu mi-a dat niciun tratament in afara de vigantolleten tonotil si liv52, astea pt ca i-am spus eu ca sunt cam slabuta,pe bilet scrie tiroidita Hashimoto si EUTIROIDIE ,dar a zis sa nu iau pe perioade lungi -BETADINA
-PROPOLIS
-SPIRULINA
-ECHINACEEA
ati putea sa-mi spuneti de ce?
miki-miki spune:
Bobocut
si Mihaele am o veste buna pt voi, este o graviduta cu ANA la sub BIOGENESIS FERTILITY CENTER. Este vb de Pysypisi. A desc ca are anticorpi antinucleari cand era deja gravi, a luat prednison dar nu stiu ce doza. Deci se poate
Anita stiu ca Echinaceea creste TH2 adica limfocitele B iar o supracestere a ac nu face bine tiroidei. Spirulina e buna pt ca are iod dar nu stiu de ce ti-a zis sa nu iei prea mult timp.
Miki Anul asta pun d'un pui.
DOAMNE AJUTA sa se prinda bb! DOAMNE AJUTA sa duc sarcina la termen!
MTHFR C677T homozigot + Fact V Leiden heterozigot + Prot S la limita inferioara + NK mari
2 sarcini oprite din evolutie (8s,5s)
ANITA75 spune:
miki ,mama omida noastra multumesc,deci n-ar fi ceva rau
miki-miki spune:
Anita
Fetelor, hai sa va spun ce am aflat azi. Am rugat o prietena sa intrebe dr ei despre cazul meu. Raspunsul a fost ca tb sa tratez trombofilia in primul rand iar pt NK nu am voie sa iau cortizon deoarece la NK active cum am eu ac ii va inmulti
Solutia ar fi progesteron cat mai mult (cred ca e vb de prog oral sau injectabil) sau imunoglobulina.
Gasii asta:
"A model of hormonal regulation of NK cells in pregnancy. In pregnancy, progesterone causes a decrease in peripheral NK cell numbers, activation, and cytotoxicity via direct action on NK cells and/or through promoting Th2 cytokine and PIBF production by T cells. It also facilitates NK cell homing to the endometrium, via inducing expression of homing receptors and addressins on peripheral NK cells and the endometrium, respectively, and possibly through induction of VEGF and MIP-1ß expression by the endometrium. Endometrial stromal cells, under the influence of progesterone, produce IL-15, prolactin, and likely other unidentified factors, which may regulate uNK cell proliferation, differentiation, and production of cytokines and other molecules that support placental and trophoblast development and promote local immunomodulation. , CD56bright CD16– NK cells; , CD56dim CD16+ NK cells."
de aici: http://edrv.endojournals.org/cgi/content/full/26/1/44/F1
Acum spun ce am aflat eu de pe net: cortizonul nu facea decat ca NK sa nu atace embrionul/placenta dar ei eliminau in continuoare citochinele care sunt toxice. Solutia este sa-i reducem sau macar sa le slabim activitatea .
Tot dr a spus ca tb sa-mi fac anal pt herpes sa vad dc o am activa, eu sunt posesoare de virus si culmea e ca mi se declanseaza dupa FIV. Dc e activa ceea ce cred ca da tb sa fac un tratam inainte de FIV cu VALTREX . No ... cred ca nici nu mai fac analiza si trec direct la tratament. Dc iau cortizon ac imi va slabi sist imunitar si mi se va declansa herpesul.
Multumesc prietenei mele inca odata, stiu ca ma va citi
Miki Anul asta pun d'un pui.
DOAMNE AJUTA sa se prinda bb! DOAMNE AJUTA sa duc sarcina la termen!
MTHFR C677T homozigot + Fact V Leiden heterozigot + Prot S la limita inferioara + NK mari
2 sarcini oprite din evolutie (8s,5s)
miki-miki spune:
D. NK cells and current RPL therapies
Given the poor understanding of the precise mechanisms underlying unexplained RPL, therapy so far has been empirical and not evidence-based. Treatment modalities for RPL include aspirin, heparin, progesterone, hCG, prednisone, leukocyte immunization, and iv Ig (3, 171, 172). Some of these therapies, namely leukocyte immunization and iv Ig, have been pursued as different approaches of immunomodulation to down-regulate the maternal immune response to the embryo.
Only treatment with aspirin and heparin in women with antiphospholipid syndrome has shown documented efficacy in well-conducted, prospective, randomized trials (3). Treatment of women with hereditary thrombophilia with low-molecular weight heparin has had some success (173, 174); however, prospective randomized controlled trials (RCTs) are still needed. Progesterone treatment early in pregnancy in women with RPL has been examined in a metaanalysis of four small controlled trials, which suggested a beneficial effect (175). Preliminary results from Brigham and Women’s Hospital (Boston, MA) have shown that women with Th1 immunity to trophoblast are treated effectively with 100 mg twice a day of progesterone vaginal suppositories beginning 3 d after ovulation (171). However, randomized clinical trials on the use of progesterone in RPL have not been performed, and such trials will be difficult to conduct in the United States because of the practice of commonly treating patients with unexplained RPL with supplemental progesterone vaginal suppositories.
Prednisone and hCG have been studied in RCTs and have been found to be ineffective (176, 177, 178). With regard to paternal leukocyte immunization in RPL, there have been five published RCTs, only one of which showed a beneficial effect (172). In the latter study, methods of randomization were not well defined, and data analysis was somewhat unconventional (179). Furthermore, a metaanalysis using individual patient data showed no benefit of leukocyte immunization (180). Similarly, there have been six RCTs of iv Ig treatment of unexplained RPL; four showed no benefit, and two showed a benefit. These studies were reviewed in a metaanalysis of individual patient data that revealed no statistically significant benefit for iv Ig in unexplained RPL (181). Finally, a recent RCT from Denmark confirmed no benefit in an intention-to-treat analysis (182). Therefore, there is no solid evidence supporting the use of either paternal leukocyte immunization or iv Ig in the treatment of unexplained RPL.
It is interesting that two of the most commonly used therapeutics in RPL affect NK cell function. Heparin, in addition to its anticoagulant effects, is known to suppress NK cell cytotoxicity (183, 184) and antagonize IFN- action by inhibiting its binding to the cell surface (185, 186). The second therapy, progesterone, can inhibit Th1 cytokine release and reduce embryotoxicity by trophoblast-activated PBMC cultures from women with RPL (139). A recent study of women with unexplained infertility has shown that ovarian stimulation with gonadotropins and progesterone results in a decrease in Th1 CD4+ cells, NK cells, and NK cell activity (187). Such treatment also results in a decrease in the levels of plasma IFN- and IL-2 and an increase in TGF-ß1 (187). Whether these changes translate into higher numbers of successful pregnancies, however, remains to be determined through RCTs.
Thus, currently, treatment for unexplained RPL remains empiric. Prospective randomized trials for use of heparin or progesterone in women with unexplained RPL are still needed to document efficacy of these modalities in this patient population. Certainly, from a theoretical standpoint, they would be rational therapeutic tools, given their immunomodulatory effects. Understanding the exact mechanism of NK cell involvement in the pathogenesis of unexplained RPL will hopefully identify more targets for the development of new and effective therapies.
Miki Anul asta pun d'un pui.
DOAMNE AJUTA sa se prinda bb! DOAMNE AJUTA sa duc sarcina la termen!
MTHFR C677T homozigot + Fact V Leiden heterozigot + Prot S la limita inferioara + NK mari
2 sarcini oprite din evolutie (8s,5s)
miki-miki spune:
Deci heparina+progesteron = un tratam bun pt NK.
Miki Anul asta pun d'un pui.
DOAMNE AJUTA sa se prinda bb! DOAMNE AJUTA sa duc sarcina la termen!
MTHFR C677T homozigot + Fact V Leiden heterozigot + Prot S la limita inferioara + NK mari
2 sarcini oprite din evolutie (8s,5s)
goldi spune:
Miki, printre multele tratamente pe care le-am incercat pe mine, a fost si valtrexul, care este un aciclovir mai evoluat.
Nu pot spune ca a avut efect,cel putin imediat, pt ca primul FIV nu a reusit.Si mie mi-a iesit analiza la virus pozitiva, dar cum am avut si rubeola in copilarie, este posibil sa interfere.
Substantele naturale care mai ales in caz de sarcina moduleaza raspunsul imun, sunt progesteronul si bHCG (pregnyl sau ovitrelle).
Totusi, nu as lasa total deoparte prednisonul - sigur, in cazul unei trombofilii, situatia se complica, insa in alte protocoale din strainatate - sunt forumuri ca DC nenumarate in SUA, Anglia, India, etc - unde fetele de acolo au aceleasi probleme ca ale noastre dar metode mai evoluate de a le trata, se dau toate: prednison, heparina, aspenter, intralipid sau imunoglobuline, viagra (scade local NK si creste vascularizatia),omega 3.
Miki, in cazul tau, NK au avut o crestere tranzitorie, poate ca acum au revenit la o valoare normala si nici nu mai trebuie sa te complici.
"Mult timp am avut impresia ca viata mea va incepe in curand, adevarata mea viata !...
In final, am inteles insa ca obstacolele reprezinta de fapt viata ." Alfred Souza
ANAR spune:
Buna fetelor!
eu sufer de hipotiroidie autoimuna, sub tratament cu euthyrox de 100 mg, la ultimele analize (in noiembrie) aveam TSH-ul=1,00 si ATPO=350.
Incerc sa raman gravida de 2 ani.
Am descoperit aceasta tiroidita in urma cu doi ani, atunci cand am decis sa facem un copil si mi-am facut mai toate analizele(TSH-ul=13, ATPO=900).
Initial am incercat s-o tratez homeopat, am cam bajbait la inceput, pana la urma m-am resemnat si am trecut la substituitie hormonala.
Si inca o buba, in urma unei SEU, acum 13 ani, am ramas cu o singura trompa...