studiu hiperprolactinemie

fetelor, cele care stiti engleza, merita sa cititi ce va copy acum. am primit acest material de la un prieten de nadejde.Este un studiu pe pacienti cu prl si cu macroadenoame hipofizare.Cititi si va minunati ce bun e dostinexul(cabergolina)...
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Cabergoline.
Cabergoline has a longer duration of action than other available dopamine agonists and is usually administered once or twice weekly. Since its introduction, it has surpassed bromocriptine as the first-line therapeutic choice for most patients. The long half-life of cabergoline is a result of its high affinity for D2 receptors on lactotrophs[306] and a greater propensity of the drug to remain in pituitary tissue.[306] [348]
In pharmacokinetic studies, cabergoline lowered PRL in a dose-related manner.[349] [350] PRL levels were normalized in 83% of 459 women with hyperprolactinemia treated with cabergoline (0.5 to 1 mg twice weekly) and in 52% of women receiving bromocriptine (2.5 to 5 mg twice daily). Cabergoline was also more effective than bromocriptine in restoring ovulatory cycles and fertility (72% versus 52%; P <.001), was better tolerated than bromocriptine, and caused fewer but similar side effects (Fig. 8-26) (see Table 8-14) . Tumor size decreased in 11 of 15 patients with macroadenomas, and menses resumed in three of four premenopausal women.[351] In our experience, bromocriptine or pergolide is as effective or almost as effective as cabergoline. In 85 patients with macroprolactinomas treated with cabergoline (0.25 to 10.5 mg/week), PRL concentrations were normalized in 61% of patients, decreased by at least 75% in an additional 24 patients, and tumor size decreased in 66% of patients. Nine patients were resistant to cabergoline despite doses of up to 7 mg/week.[352] [353] Despite the continued experience that a subset of hyperprolactinemic patients are resistant to most or all dopamine agonists, a report indicated that cabergoline normalized PRL in 15 of 19 patients with macroprolactinomas previously resistant to other dopamine agonists.[338] "
daca aveti intrebari, nu ezitati.Am si un tabel cu studiu de caz dar nu mi se copy calumea.Pt cele interesate, pot trimite mail.
va pup, doly

cali spune:

doly, trimite-mi si mie te rog mai multe informatii pe mail. Ma intereseaza ptr ca si eu am PRL mare, si iau bromcriptina de 1 an aproape.. tu iei dostinex? ai idee cat costa? multumesc